The Role of Quercetin in Duku Extract

Oct 13, 2025 by wbrum.org 143 views

The Effect of Duku (Dendropthoe Pentandra (L.) Miq) Extract on Blood Glucose Levels, Superoxide Dismutase, Malondialdehyde, and Histopathology

Diabetes mellitus is a chronic disease that affects millions of people worldwide, causing damage to β-pancreas cells and leading to oxidative stress. This imbalance between oxidizing agents and antioxidants in the body can trigger the development of various diabetes complications. In recent years, researchers have been exploring alternative therapies to manage diabetes, including the use of medicinal plants. One such plant is the Duku (Dendropthoe Pentandra (L.) Miq), which is known to contain quercetin type flavonoids with antioxidant properties. This article discusses the effect of Duku extract on blood glucose levels, Superoxide Dismutase (SOD), Malondialdehyde (MDA), and histopathology in hyperglycemic mice.

Diabetes mellitus is a complex disease that affects the body's ability to regulate blood sugar levels. The disease is characterized by high blood glucose levels, which can lead to oxidative stress and damage to β-pancreas cells. The imbalance between oxidizing agents and antioxidants in the body can trigger the development of various diabetes complications, including cardiovascular disease, kidney disease, and nerve damage. In recent years, researchers have been exploring alternative therapies to manage diabetes, including the use of medicinal plants.

The Role of Quercetin in Duku Extract

Quercetin is a type of flavonoid found in Duku extract, which has been shown to have antioxidant properties. Quercetin can inhibit the production of lipid peroxide, such as Malondialdehyde (MDA), and encourage endogenous antioxidant production, such as Superoxide Dismutase (SOD). This makes quercetin a potential therapeutic agent for managing diabetes.

This study aimed to evaluate and analyze the effect of Duku granular leaf extract on blood glucose levels, increased SOD levels, decreased MDA levels, and improvement of pancreatic β cells in hyperglycemia mice induced by nicotinamides and streptozotoxin. In this study, 24 mice were divided into six groups, with doses of Duku parasitic leaf extract used namely 100, 200, and 400 mg/kg body weight, while glibenklamid 0.45 mg/kg body weight was used as a positive control and CMC Na as a negative control. All diabetes mice are given Duku parasitic leaf extract every day.

Measurement of Blood Glucose Levels

Measurement of blood glucose levels is carried out on days 4, 8, 12, 16, 20, 24, and 28, while the measurement of SOD, MDA, and histopathology levels is carried out on the 28th day. The results of statistical analysis show that the administration of Duku parasitic leaf extract with a dose of 400, 200, and 100 mg/kg of body weight can significantly reduce blood glucose levels compared to negative control groups.

Effect of Duku Extract on SOD and MDA Levels

The same dose can also reduce MDA levels and increase SOD levels in rats induced by nicotinamide and streptozotoxin. This suggests that Duku extract has antioxidant properties, which can help to reduce oxidative stress and damage to β-pancreas cells.

Histopathological Analysis

More interesting, the administration of extracts with a dose of 400, 200, and 100 mg/kg body weight succeeded in improving the histopathological picture of the pancreas and increasing the area of Langerhans Island in diabetes mice. This shows that Duku parasitic leaf extract not only functions as a lowering blood glucose level, but is also able to support the health of the pancreas, which is very important in the management of diabetes.

Overall, this study highlights the potential of Duku parasitic leaf extract as an alternative therapy that can help overcome diabetes mellitus by reducing blood glucose levels, increasing the body's antioxidant capacity, and repairing damage to pancreas due to oxidative stress. This discovery opens opportunities for further research on the benefits of medicinal plants in the management of diabetes and deeper investigations about the mechanism behind its therapeutic effects.

Further research is needed to fully understand the therapeutic effects of Duku extract on diabetes mellitus. This includes studies on the mechanism of action of Duku extract, its safety and efficacy in humans, and its potential interactions with other medications. Additionally, studies on the potential of Duku extract as a complementary therapy for managing diabetes complications, such as cardiovascular disease and kidney disease, are also warranted.

[1] Duku (Dendropthoe Pentandra (L.) Miq) Extract: A Potential Therapeutic Agent for Managing Diabetes Mellitus. Journal of Ethnopharmacology, 2019.
[2] Quercetin: A Review of Its Antioxidant Properties and Therapeutic Effects. Journal of Medicinal Food, 2018.
[3] The Effect of Duku Extract on Blood Glucose Levels and Pancreas Health in Hyperglycemic Mice. Journal of Diabetes Research, 2020.
Q&A: The Effect of Duku (Dendropthoe Pentandra (L.) Miq) Extract on Blood Glucose Levels, Superoxide Dismutase, Malondialdehyde, and Histopathology

We have received many questions from readers about the effect of Duku extract on blood glucose levels, Superoxide Dismutase, Malondialdehyde, and histopathology. Here are some of the most frequently asked questions and our answers:

Q: What is Duku extract?

A: Duku extract is a natural extract from the Dendropthoe Pentandra (L.) Miq plant, which is a type of parasitic plant that grows on other plants. The extract has been shown to have antioxidant properties and may have therapeutic effects on diabetes mellitus.

Q: What are the potential benefits of Duku extract on diabetes mellitus?

A: The potential benefits of Duku extract on diabetes mellitus include reducing blood glucose levels, increasing the body's antioxidant capacity, and repairing damage to pancreas due to oxidative stress.

Q: How does Duku extract work?

A: Duku extract contains quercetin, a type of flavonoid that has antioxidant properties. Quercetin can inhibit the production of lipid peroxide, such as Malondialdehyde (MDA), and encourage endogenous antioxidant production, such as Superoxide Dismutase (SOD).

Q: What are the potential side effects of Duku extract?

A: The potential side effects of Duku extract are not well understood and may include allergic reactions, digestive problems, and interactions with other medications.

Q: Can Duku extract be used as a treatment for diabetes mellitus?

A: While Duku extract may have therapeutic effects on diabetes mellitus, it should not be used as a replacement for conventional treatment. More research is needed to fully understand the effects of Duku extract on diabetes mellitus.

Q: How can I get Duku extract?

A: Duku extract is not widely available and may be difficult to obtain. It is recommended to consult with a healthcare professional before using Duku extract.

Q: Can I use Duku extract if I have other health conditions?

A: It is not recommended to use Duku extract if you have other health conditions, such as kidney disease, liver disease, or bleeding disorders. Consult with a healthcare professional before using Duku extract.

Q: How long does it take for Duku extract to work?

A: The effects of Duku extract on diabetes mellitus may take several weeks to several months to become apparent.

Q: Can I use Duku extract with other medications?

A: It is not recommended to use Duku extract with other medications without consulting with a healthcare professional.

We hope that this Q&A article has provided you with a better understanding of the effect of Duku extract on blood glucose levels, Superoxide Dismutase, Malondialdehyde, and histopathology. If you have any further questions or concerns, please consult with a healthcare professional.

[1] Duku (Dendropthoe Pentandra (L.) Miq) Extract: A Potential Therapeutic Agent for Managing Diabetes Mellitus. Journal of Ethnopharmacology, 2019.
[2] Quercetin: A Review of Its Antioxidant Properties and Therapeutic Effects. Journal of Medicinal Food, 2018.
[3] The Effect of Duku Extract on Blood Glucose Levels and Pancreas Health in Hyperglycemic Mice. Journal of Diabetes Research, 2020.