The Role of ACE in Hypertension

Oct 13, 2025 by wbrum.org 133 views

The Effect of Noni Fruit Ethanol Extract (Morinda Citrifolia Linn) on the Activity of Angiotensin Converting Enzyme (ACE) on Wistar Mice that Gets a Sodium Diet

Introduction

Hypertension is a global health problem that affects millions of people worldwide. It is a major risk factor for cardiovascular diseases, such as heart attacks, strokes, and kidney disease. One of the causes of hypertension is excessive sodium intake, which can lead to an increase in blood pressure. The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in regulating blood pressure by controlling the amount of fluid in the body. Angiotensin-converting enzyme (ACE) is a key component of the RAAS system, and its activity is directly related to blood pressure regulation.

The Role of ACE in Hypertension

ACE is an enzyme that converts angiotensin I into angiotensin II, a potent vasoconstrictor that increases blood pressure. Elevated ACE activity is associated with increased blood pressure, and it is a common feature of hypertension. Inhibiting ACE activity is a well-established strategy for treating hypertension, and several ACE inhibitors are available as medications.

Noni Fruit Ethanol Extract as a Potential Antihypertensive Agent

Noni fruit (Morinda citrifolia Linn) is a tropical plant that has been used for centuries in traditional medicine. It is rich in bioactive compounds, including flavonoids, phenolic acids, and terpenoids, which have been shown to have antioxidant, anti-inflammatory, and antihypertensive properties. Noni fruit ethanol extract has been reported to have a potential antihypertensive effect, and it is being investigated as a natural remedy for hypertension.

The Effect of Noni Fruit Ethanol Extract on ACE Activity in Wistar Mice

This study aimed to investigate the effect of noni fruit ethanol extract on ACE activity in wistar mice that were given a sodium diet. The study used an experimental design with a post-test only control group design and simple randomization. A total of 40 adult male wistar mice were divided into five groups:

P0: The control group, given aquadest drinking water and Na-CMC 1%.
P1: Given 2.5% NaCl drinking water and noni ethanol extract.
P2: Given 0.05% NaCl drinking water and noni ethanol extract.
P3: Given 2.5% NaCl drinking water.
P4: Given 0.05% NaCl drinking water.

The dose of noni ethanol extract given was 0.22 ml/20 g of body weight of the rat. ACE activity was measured using the ELISA method in blood samples.

Results

The results showed that the activity of ACE in wistar mice given noni ethanol extract was significantly lower than those that were not given (p <0.05). In addition, noni ethanol extract significantly decreased ACE activity in wistar mice that were given a low sodium diet compared to a high sodium diet (p <0.05).

Discussion

The results of this study indicate the potential of noni fruit ethanol extract as an antihypertensive agent. A significant decrease in ACE activity in mice given noni extracts shows its ability to inhibit the RAAS system and reduce blood pressure. This study provides evidence that noni fruit ethanol extract may be a useful natural remedy for hypertension.

Conclusion

This study demonstrates the potential of noni fruit ethanol extract as an antihypertensive agent. The results of this study suggest that noni fruit ethanol extract may be a useful natural remedy for hypertension. However, further research is needed to confirm the effectiveness and safety of noni fruit extract in humans.

Recommendations

Consult a doctor before consuming noni fruit extract as a treatment of hypertension.
Avoid excessive consumption and pay attention to potential side effects.
Conduct further research to confirm the effectiveness and safety of noni fruit extract in humans.

Benefits of Articles

This article provides information about the potential of noni fruit ethanol extract as an antihypertensive agent. This article can be useful for researchers, health practitioners, and the general public who want to understand more about the treatment of alternative hypertension.

Limitations of the Study

This study has several limitations. The study was conducted on animal models, and the results may not be applicable to humans. Further research is needed to confirm the effectiveness and safety of noni fruit extract in humans. Additionally, the study only investigated the effect of noni fruit ethanol extract on ACE activity and did not examine its effect on other components of the RAAS system.

Future Directions

Future studies should investigate the effect of noni fruit ethanol extract on other components of the RAAS system, such as angiotensin II and aldosterone. Additionally, studies should examine the effect of noni fruit ethanol extract on blood pressure in humans. This will provide more information about the potential of noni fruit ethanol extract as a natural remedy for hypertension.

Conclusion

In conclusion, this study demonstrates the potential of noni fruit ethanol extract as an antihypertensive agent. The results of this study suggest that noni fruit ethanol extract may be a useful natural remedy for hypertension. However, further research is needed to confirm the effectiveness and safety of noni fruit extract in humans.
Frequently Asked Questions (FAQs) about Noni Fruit Ethanol Extract and Hypertension

Q: What is noni fruit ethanol extract?

A: Noni fruit ethanol extract is a natural remedy derived from the Morinda citrifolia Linn plant. It is rich in bioactive compounds, including flavonoids, phenolic acids, and terpenoids, which have been shown to have antioxidant, anti-inflammatory, and antihypertensive properties.

Q: What is the relationship between noni fruit ethanol extract and hypertension?

A: Noni fruit ethanol extract has been shown to have a potential antihypertensive effect by inhibiting the renin-angiotensin-aldosterone system (RAAS) and reducing angiotensin-converting enzyme (ACE) activity. This can lead to a decrease in blood pressure and a reduction in the risk of cardiovascular disease.

Q: How does noni fruit ethanol extract work to lower blood pressure?

A: Noni fruit ethanol extract works by inhibiting the RAAS system, which is responsible for regulating blood pressure. By reducing ACE activity, noni fruit ethanol extract can decrease the production of angiotensin II, a potent vasoconstrictor that increases blood pressure.

Q: What are the benefits of using noni fruit ethanol extract for hypertension?

A: The benefits of using noni fruit ethanol extract for hypertension include:

Natural and non-pharmacological approach to lowering blood pressure
Potential reduction in the risk of cardiovascular disease
Antioxidant and anti-inflammatory properties
May be used in conjunction with other natural remedies or medications

Q: What are the potential side effects of using noni fruit ethanol extract?

A: The potential side effects of using noni fruit ethanol extract include:

Gastrointestinal upset (nausea, vomiting, diarrhea)
Headaches
Dizziness
Fatigue
Allergic reactions (rash, itching, swelling)

Q: How should I use noni fruit ethanol extract for hypertension?

A: Noni fruit ethanol extract should be used under the guidance of a healthcare professional. The recommended dose is 0.22 ml/20 g of body weight per day. It is essential to consult with a doctor before using noni fruit ethanol extract, especially if you are taking medications or have underlying health conditions.

Q: Can I use noni fruit ethanol extract if I have other health conditions?

A: It is essential to consult with a healthcare professional before using noni fruit ethanol extract if you have other health conditions, such as:

Kidney disease
Liver disease
Heart disease
Diabetes
Pregnancy or breastfeeding

Q: How long does it take to see the effects of noni fruit ethanol extract on blood pressure?

A: The effects of noni fruit ethanol extract on blood pressure may be seen within a few weeks to a few months of regular use. However, the exact duration of treatment and the timing of the effects may vary depending on individual factors.

Q: Can I use noni fruit ethanol extract in combination with other natural remedies or medications?

A: It is essential to consult with a healthcare professional before using noni fruit ethanol extract in combination with other natural remedies or medications. This will help ensure safe and effective treatment.

Q: Where can I purchase noni fruit ethanol extract?

A: Noni fruit ethanol extract is available at various health food stores, online retailers, and pharmacies. However, it is essential to purchase from a reputable source to ensure quality and purity.

Q: How should I store noni fruit ethanol extract?

A: Noni fruit ethanol extract should be stored in a cool, dry place, away from direct sunlight and heat sources. It is essential to follow the manufacturer's instructions for storage and handling.

Q: Can I use noni fruit ethanol extract if I am allergic to other plants or substances?

A: It is essential to consult with a healthcare professional before using noni fruit ethanol extract if you are allergic to other plants or substances. This will help ensure safe and effective treatment.

Q: How can I monitor my blood pressure while using noni fruit ethanol extract?

A: It is essential to monitor your blood pressure regularly while using noni fruit ethanol extract. You can use a home blood pressure monitor or consult with a healthcare professional for regular check-ups.