The Relationship Between Polymorphism BDNF Val66met and the Events of Childhood Trauma in People with Batak Schizophrenia

Oct 13, 2025 by wbrum.org 41 views

The Relationship Between Polymorphism BDNF Val66met and the Events of Childhood Trauma in People with Batak Schizophrenia

Introduction

Schizophrenia is a severe brain disease characterized by severe and prolonged psychotic symptoms, and is accompanied by impaired cognitive and psychosocial function. A number of studies have shown that the cause of schizophrenia is a combination of genetic and environmental factors. One of the genetic candidates that is often considered is the BDNF Val66Met polymorphism, while the trauma of childhood is considered an environmental factor that has the potential to be related to schizophrenia. This study aims to analyze the relationship between Polymorphism BDNF Val66met and childhood trauma in individuals with schizophrenia from the Batak tribe compared to healthy individuals from the same tribe.

Background

Schizophrenia is a complex condition that affects millions of people worldwide. The exact cause of schizophrenia is still not fully understood, but it is believed to be a combination of genetic and environmental factors. The BDNF Val66Met polymorphism is one of the many genetic variants that have been studied in various contexts, including mental disorders. BDNF (Brain-Derved Neurotrophic Factor) plays an important role in the development and function of the nervous system, including learning and memory processes. Therefore, every change in this gene can have an impact on the way the brain functions.

Childhood trauma is one of the risk factors that is often ignored in schizophrenia understanding. Research shows that bad experiences in childhood, such as harassment or neglect, can trigger mental health problems later on. The trauma of childhood can have a significant impact on the development of schizophrenia, and it is essential to understand the relationship between childhood trauma and schizophrenia.

Methodology

The method used in this study is a multivariate comparative analytic study with a case-control design. Blood samples are taken from a total of 200 subjects, with 100 subjects from groups of people with schizophrenia (ODS) and control groups. Then, the identification of allele and genotype BDNF Val66met is carried out using the Polymerase Chain-Restriction Fragment Length Polymorphism (PCR-RFLP) technique.

Results

The results showed the absence of a significant relationship between the BDNF Val66Met polymorphism allele on ODS and healthy control, with a P value of 0.107 and ODDS Ratio (OR) 1,413 (95% CI: 0.951-2.099). Further analysis of the Genotype of Polymorphism BDNF Val66met also shows similar results, with no significant relationship between Genotype Met/MET compared to Val/Val (P = 0.063, OR 0.486) and VAL/MET compared to Val/Val (P = 0.291, OR 1,414). Meanwhile, there is a significant relationship between child mass trauma in the domain of CM (Childhood Maltreatment) and FD (Family Dysfunction) with a P value <0.001, each showing OR 5,096 and 10,778. However, for the Vio domain (violence) there was no significant relationship with P = 0.056.

Discussion

The findings of this study provide new insights on how the environment and life experiences can contribute to the development of schizophrenia, regardless of genetic factors. The significant relationship between child mass trauma in the domain of CM and FD with ODS suggests that childhood trauma plays a crucial role in the development of schizophrenia. The absence of a significant relationship between the BDNF Val66Met polymorphism allele and genotype with ODS and healthy control suggests that the BDNF Val66Met polymorphism does not contribute significantly to the development of schizophrenia.

Conclusion

The conclusion of this study is the absence of a relationship between alleles and genotypes of BDNF Val66 met polymorphism between individuals with schizophrenia and healthy control. However, a significant relationship was found between the trauma of the child's mass in the cm and FD domains between the two groups. Overall, this study shows the importance of the role of childhood trauma in the development of schizophrenia, although BDNF Val66Met polymorphism does not contribute significantly to the trauma.

Implications

The findings of this study have significant implications for the prevention and intervention of schizophrenia. The importance of understanding the relationship between genetic and environmental factors in the context of schizophrenia cannot be underestimated. BDNF Val66Met polymorphism is one of the many genetic variants that have been studied in various contexts, including mental disorders. BDNF (Brain-Derved Neurotrophic Factor) plays an important role in the development and function of the nervous system, including learning and memory processes. Therefore, every change in this gene can have an impact on the way the brain functions.

Recommendations

Based on the findings of this study, the following recommendations are made:

Early intervention: Early intervention is crucial in preventing the development of schizophrenia. Identifying children who are at risk of developing schizophrenia due to childhood trauma is essential.
Prevention: Preventing childhood trauma is essential in preventing the development of schizophrenia. This can be achieved through education and awareness programs that promote healthy parenting practices.
Treatment: Treatment of schizophrenia should focus on addressing the underlying causes of the disorder, including childhood trauma.
Research: Further research is needed to understand the relationship between genetic and environmental factors in the context of schizophrenia.

Limitations

This study has several limitations. The sample size was small, and the study was conducted in a specific population. Further studies are needed to confirm the findings of this study and to generalize the results to other populations.

Future Directions

The findings of this study provide new insights on how the environment and life experiences can contribute to the development of schizophrenia, regardless of genetic factors. Further studies are needed to understand the relationship between genetic and environmental factors in the context of schizophrenia. The importance of understanding the relationship between childhood trauma and schizophrenia cannot be underestimated. Research shows that bad experiences in childhood, such as harassment or neglect, can trigger mental health problems later on. The trauma of childhood can have a significant impact on the development of schizophrenia, and it is essential to understand the relationship between childhood trauma and schizophrenia.

Conclusion

In conclusion, this study provides new insights on how the environment and life experiences can contribute to the development of schizophrenia, regardless of genetic factors. The significant relationship between child mass trauma in the domain of CM and FD with ODS suggests that childhood trauma plays a crucial role in the development of schizophrenia. The absence of a significant relationship between the BDNF Val66Met polymorphism allele and genotype with ODS and healthy control suggests that the BDNF Val66Met polymorphism does not contribute significantly to the development of schizophrenia.
Q&A: The Relationship Between Polymorphism BDNF Val66met and the Events of Childhood Trauma in People with Batak Schizophrenia

Q: What is the BDNF Val66Met polymorphism?

A: The BDNF Val66Met polymorphism is a genetic variation in the brain-derived neurotrophic factor (BDNF) gene. BDNF plays an important role in the development and function of the nervous system, including learning and memory processes.

Q: What is the relationship between the BDNF Val66Met polymorphism and schizophrenia?

A: The BDNF Val66Met polymorphism has been studied in various contexts, including mental disorders. However, the results of this study suggest that the BDNF Val66Met polymorphism does not contribute significantly to the development of schizophrenia.

Q: What is the relationship between childhood trauma and schizophrenia?

A: Childhood trauma is one of the risk factors that is often ignored in schizophrenia understanding. Research shows that bad experiences in childhood, such as harassment or neglect, can trigger mental health problems later on. The trauma of childhood can have a significant impact on the development of schizophrenia.

Q: What are the domains of childhood trauma that were studied in this research?

A: The domains of childhood trauma that were studied in this research include:

CM (Childhood Maltreatment)
FD (Family Dysfunction)
Vio (Violence)

Q: What were the results of the study regarding the relationship between childhood trauma and schizophrenia?

A: The results of the study showed a significant relationship between child mass trauma in the domain of CM and FD with ODS (individuals with schizophrenia). However, there was no significant relationship between the Vio domain and ODS.

Q: What are the implications of this study for the prevention and intervention of schizophrenia?

A: The findings of this study have significant implications for the prevention and intervention of schizophrenia. The importance of understanding the relationship between genetic and environmental factors in the context of schizophrenia cannot be underestimated. Childhood trauma is one of the risk factors that is often ignored in schizophrenia understanding, and it is essential to understand the relationship between childhood trauma and schizophrenia.

Q: What are the recommendations for early intervention, prevention, treatment, and research based on the findings of this study?

A: Based on the findings of this study, the following recommendations are made:

Early intervention: Early intervention is crucial in preventing the development of schizophrenia. Identifying children who are at risk of developing schizophrenia due to childhood trauma is essential.
Prevention: Preventing childhood trauma is essential in preventing the development of schizophrenia. This can be achieved through education and awareness programs that promote healthy parenting practices.
Treatment: Treatment of schizophrenia should focus on addressing the underlying causes of the disorder, including childhood trauma.
Research: Further research is needed to understand the relationship between genetic and environmental factors in the context of schizophrenia.

Q: What are the limitations of this study?

A: This study has several limitations. The sample size was small, and the study was conducted in a specific population. Further studies are needed to confirm the findings of this study and to generalize the results to other populations.

Q: What are the future directions for research based on the findings of this study?

A: The findings of this study provide new insights on how the environment and life experiences can contribute to the development of schizophrenia, regardless of genetic factors. Further studies are needed to understand the relationship between genetic and environmental factors in the context of schizophrenia. The importance of understanding the relationship between childhood trauma and schizophrenia cannot be underestimated. Research shows that bad experiences in childhood, such as harassment or neglect, can trigger mental health problems later on. The trauma of childhood can have a significant impact on the development of schizophrenia, and it is essential to understand the relationship between childhood trauma and schizophrenia.