The Importance of Lipid Profile Management in Diabetes Mellitus

Oct 13, 2025 by wbrum.org 91 views

Effects of Ethanol Extract Sikkam Leaf (Bischofia Javanica) on Lipid Profiles, Aortic Histology, and Male White Mouse Kidney Models of Diabetes Mellitus

Introduction

Diabetes mellitus is a metabolic disorder that can cause various chronic complications, with abnormalities in the lipid profile in the blood being one of the most serious complications. This lipid profile imbalance is a major cause of death in people with diabetes mellitus. The aim of this study is to evaluate the effect of sikkam leaf ethanol extract (bischofia javanica) on lipid profiles, as well as aortic and kidney histological conditions in male white mice, which become a model of diabetes mellitus.

The Importance of Lipid Profile Management in Diabetes Mellitus

Diabetes mellitus is a complex disease that affects various aspects of the body, including the cardiovascular system. Abnormalities in the lipid profile, such as high levels of total cholesterol, LDL (low-density lipoprotein), and triglycerides, and low levels of HDL (high-density lipoprotein), are common in people with diabetes mellitus. These lipid profile imbalances can increase the risk of cardiovascular disease, which is a major cause of death in people with diabetes mellitus. Therefore, managing lipid profiles is crucial in the treatment and management of diabetes mellitus.

The Potential of Sikkam Leaf Ethanol Extract in Diabetes Management

Sikkam leaf (bischofia javanica) is a plant that has been used in traditional medicine for various purposes, including the treatment of diabetes mellitus. The ethanol extract of sikkam leaf has been shown to have potential in managing diabetes mellitus, particularly in normalizing lipid profiles. This study aims to evaluate the effect of sikkam leaf ethanol extract on lipid profiles, as well as aortic and kidney histological conditions in male white mice, which become a model of diabetes mellitus.

Research Methodology

This study uses an experimental design with a non-factorial approach to a completely randomized design (CRD). A total of 30 wistar rats are divided into six different treatment groups, each repeated six times. The data are analyzed using the one-way ANOVA method followed by the BNT test, with the SPSS 2.2 application at a significance level of 0.05.

Research Results

The results showed that sikkam leaf ethanol extract had a significant effect in reducing total cholesterol levels, LDL, and triglycerides, and increasing HDL levels in male white mice. In addition, this extract is also able to improve the histological conditions of aorta and kidney in the diabetes mellitus model. The most effective dose of ethanol extract in providing improvements is 900 mg/kg of mice weight.

Additional Analysis and Explanation

This finding shows the great potential of sikkam leaves in the management of diabetes mellitus, especially in normalizing lipid profiles that are often disrupted in diabetics. Decreased levels of total cholesterol and triglycerides are important indicators, because both types of lipids are closely correlated with the risk of cardiovascular disease. In addition, an increase in HDL levels, known as "good cholesterol", provides hope for the heart health improvement of diabetics.

Improvement in the histology of aorta and kidney is also a significant finding. A good aortic structure and function contribute to healthier blood circulation, while a normally functioning kidney is very important to maintain the balance of metabolism in the body. Thus, sikkam leaf ethanol extract not only functions as a hypolipidemic agent but also provides protection against vital organs that are often affected by diabetes.

Conclusion

Ethanol extract of sikkam leaf (bischofia javanica) shows a significant positive effect on lipid profiles, as well as aortic and kidney histology in the male white mouse model with diabetes mellitus. These results open opportunities for the development of plant-based treatment that can help in diabetes management and its complications. Further research is needed to identify the mechanism of work that underlies this effect and explore the possibility of use in humans.

Future Directions

This study highlights the importance of exploration of natural ingredients as an alternative treatment that is safer and more efficient. With the increasing prevalence of diabetes mellitus throughout the world, the discovery of new drugs that are natural and have minimal side effects such as sikkam leaf extract is very important to study further. Further research is needed to identify the mechanism of work that underlies this effect and explore the possibility of use in humans.

Implications of the Study

This study has several implications for the management of diabetes mellitus. Firstly, it highlights the potential of sikkam leaf ethanol extract in normalizing lipid profiles, which is a major complication of diabetes mellitus. Secondly, it shows that sikkam leaf ethanol extract can improve the histological conditions of aorta and kidney, which are often affected by diabetes. Finally, it suggests that sikkam leaf ethanol extract can be used as a plant-based treatment for diabetes management and its complications.

Limitations of the Study

This study has several limitations. Firstly, it was conducted in male white mice, which may not be representative of humans. Secondly, the sample size was relatively small, which may not be sufficient to detect significant effects. Finally, the study did not investigate the mechanism of work that underlies the effect of sikkam leaf ethanol extract on lipid profiles and histological conditions.

Recommendations for Future Research

Based on the findings of this study, several recommendations for future research can be made. Firstly, further studies are needed to investigate the mechanism of work that underlies the effect of sikkam leaf ethanol extract on lipid profiles and histological conditions. Secondly, studies are needed to explore the possibility of use of sikkam leaf ethanol extract in humans. Finally, studies are needed to investigate the potential of sikkam leaf ethanol extract in managing other complications of diabetes mellitus.
Q&A: Effects of Ethanol Extract Sikkam Leaf (Bischofia Javanica) on Lipid Profiles, Aortic Histology, and Male White Mouse Kidney Models of Diabetes Mellitus

Q: What is the main objective of this study?

A: The main objective of this study is to evaluate the effect of sikkam leaf ethanol extract (bischofia javanica) on lipid profiles, as well as aortic and kidney histological conditions in male white mice, which become a model of diabetes mellitus.

Q: What is the significance of lipid profile management in diabetes mellitus?

A: Lipid profile management is crucial in the treatment and management of diabetes mellitus. Abnormalities in the lipid profile, such as high levels of total cholesterol, LDL (low-density lipoprotein), and triglycerides, and low levels of HDL (high-density lipoprotein), are common in people with diabetes mellitus. These lipid profile imbalances can increase the risk of cardiovascular disease, which is a major cause of death in people with diabetes mellitus.

Q: What is the potential of sikkam leaf ethanol extract in diabetes management?

A: Sikkam leaf ethanol extract has been shown to have potential in managing diabetes mellitus, particularly in normalizing lipid profiles. This study aims to evaluate the effect of sikkam leaf ethanol extract on lipid profiles, as well as aortic and kidney histological conditions in male white mice, which become a model of diabetes mellitus.

Q: What are the research methodology and results of this study?

A: This study uses an experimental design with a non-factorial approach to a completely randomized design (CRD). A total of 30 wistar rats are divided into six different treatment groups, each repeated six times. The data are analyzed using the one-way ANOVA method followed by the BNT test, with the SPSS 2.2 application at a significance level of 0.05. The results showed that sikkam leaf ethanol extract had a significant effect in reducing total cholesterol levels, LDL, and triglycerides, and increasing HDL levels in male white mice.

Q: What are the implications of this study?

A: This study has several implications for the management of diabetes mellitus. Firstly, it highlights the potential of sikkam leaf ethanol extract in normalizing lipid profiles, which is a major complication of diabetes mellitus. Secondly, it shows that sikkam leaf ethanol extract can improve the histological conditions of aorta and kidney, which are often affected by diabetes. Finally, it suggests that sikkam leaf ethanol extract can be used as a plant-based treatment for diabetes management and its complications.

Q: What are the limitations of this study?

A: This study has several limitations. Firstly, it was conducted in male white mice, which may not be representative of humans. Secondly, the sample size was relatively small, which may not be sufficient to detect significant effects. Finally, the study did not investigate the mechanism of work that underlies the effect of sikkam leaf ethanol extract on lipid profiles and histological conditions.

Q: What are the recommendations for future research?

A: Based on the findings of this study, several recommendations for future research can be made. Firstly, further studies are needed to investigate the mechanism of work that underlies the effect of sikkam leaf ethanol extract on lipid profiles and histological conditions. Secondly, studies are needed to explore the possibility of use of sikkam leaf ethanol extract in humans. Finally, studies are needed to investigate the potential of sikkam leaf ethanol extract in managing other complications of diabetes mellitus.

Q: What are the potential applications of this study?

A: The potential applications of this study are numerous. Firstly, it can be used as a plant-based treatment for diabetes management and its complications. Secondly, it can be used as a natural remedy for lipid profile management. Finally, it can be used as a potential treatment for other complications of diabetes mellitus.

Q: What are the future directions of this study?

A: The future directions of this study are to investigate the mechanism of work that underlies the effect of sikkam leaf ethanol extract on lipid profiles and histological conditions. Secondly, studies are needed to explore the possibility of use of sikkam leaf ethanol extract in humans. Finally, studies are needed to investigate the potential of sikkam leaf ethanol extract in managing other complications of diabetes mellitus.