The Importance of Gotu Kola Leaf Extract in Acne Treatment

Oct 13, 2025 by wbrum.org 128 views

The Patch Preparation Formulation of Gotu Kola Leaf Extract (Centella Asiatica) and an Antibacterial Activity Test on Propionibacterium Acne in Vitro

Introduction

Acne is a common skin condition that affects millions of people worldwide. It is caused by the bacterium Propionibacterium acnes (P. acnes), which is a major contributor to the development of acne. In an effort to overcome the problem of acne while protecting the area of acne-prone skin from contamination, a patch preparation that uses Gotu kola leaf extract (Centella asiatica) is developed. Gotu kola leaf extract is known to have various activities, including significant antibacterial effects on the bacterium P. acnes. This study aims to formulate a patch preparation from Gotu kola leaf extract which has good quality and shows antibacterial effects.

Research Methods

The research was conducted to formulate a patch preparation from Gotu kola leaf extract using a maceration method with 96% ethanol solvent. The patch formulation process was carried out with a variation of concentration using the solvent casting method. After manufacturing, the antibacterial activity test was carried out using a disc diffusion method to measure the ability of the patch in inhibiting bacterial growth.

Research Result

The resulting patch shows a distinctive color and aroma in a solid form, with physical parameters that meet the standards. The analysis shows that the patch weight has a coefficient of variation (%CV) between 2.22% - 4.80%, the thickness of the patch ranges from 0.200 ± 0,000 - 0.567 ± 0.050 mm, and folding capacity of more than 500 times. The pH patch value is also measured between 4.69 ± 0.005 - 5.17 ± 0.032. In addition, the measurement of shrinkage, absorption of humidity, and swelling also shows significant values. In phosphate media at pH 5.8, the patch swelling ranges from 45.96% - 76.11%, while in distillation water is in the range of 54.5% - 80%.

In testing antibacterial activity, Gotu kola leaf extract with a concentration of 10% shows the largest inhibition zone with a diameter of 11.3 mm. Meanwhile, the patch preparation from Gotu kola extract shows the maximum inhibitory zone in the F5 formulation with a diameter of 9.80 mm.

Conclusion

Patch preparations from Gotu kola leaf extract meet all physical test requirements, which indicates that the patch formulation with Gotu kola leaf extract produces good quality products. Antibacterial tests show that Gotu kola leaf extract patch, especially in the formulations of F3, F4, and F5, each has an inhibitory zone with a diameter of 8.83 mm; 9.20 mm; and 9.80 mm. This shows that the resulting patch has a potential antibacterial effect.

The Importance of Gotu Kola Leaf Extract in Acne Treatment

Gotu kola leaf extract has been widely used in traditional medicine for its various health benefits, including its antibacterial effects. The study of the effectiveness of Gotu kola leaf extract on acne has shown promising results, with many studies indicating its potential as a safe and effective treatment for acne. The use of Gotu kola leaf extract in patch preparations has been shown to be effective in inhibiting the growth of P. acnes, making it a potential treatment for acne.

Future Directions

This study has shown the potential of Gotu kola leaf extract in the treatment of acne. However, further studies are needed to fully understand its effects and to develop more effective and safe treatments. The use of Gotu kola leaf extract in patch preparations has been shown to be effective, but more research is needed to optimize its formulation and to determine its long-term effects.

Useful Resources

Zulkifli, M., et al. (2022). "The use of gotu kola leaf extract as an acne medicine: Systematic Review". Journal of Pharmacy and Pharmaceutical Sciences.
Rahmawati, N. (2020). "The study of the effectiveness of gotu kola leaf extract on acne". Journal of Dermatology.
Ministry of Health of the Republic of Indonesia. (2021). "Guidelines for the Use of Medicinal Plants".

Conclusion

In conclusion, this study has shown the potential of Gotu kola leaf extract in the treatment of acne. The patch preparation formulation from Gotu kola leaf extract has been shown to be effective in inhibiting the growth of P. acnes, making it a potential treatment for acne. Further studies are needed to fully understand its effects and to develop more effective and safe treatments.
Q&A: The Patch Preparation Formulation of Gotu Kola Leaf Extract (Centella Asiatica) and an Antibacterial Activity Test on Propionibacterium Acne in Vitro

Frequently Asked Questions

We have received many questions from readers about the patch preparation formulation of Gotu kola leaf extract (Centella asiatica) and its antibacterial activity test on Propionibacterium acne in vitro. Here are some of the most frequently asked questions and our answers:

Q: What is Gotu kola leaf extract and how does it work?

A: Gotu kola leaf extract is a natural ingredient that has been used in traditional medicine for its various health benefits, including its antibacterial effects. It works by inhibiting the growth of Propionibacterium acne, the bacterium that causes acne.

Q: What is the patch preparation formulation and how is it made?

A: The patch preparation formulation is a type of skin patch that is made from Gotu kola leaf extract. It is made using a maceration method with 96% ethanol solvent and a solvent casting method.

Q: What are the physical parameters of the patch preparation formulation?

A: The physical parameters of the patch preparation formulation include its weight, thickness, folding capacity, and pH value. The patch weight has a coefficient of variation (%CV) between 2.22% - 4.80%, the thickness of the patch ranges from 0.200 ± 0,000 - 0.567 ± 0.050 mm, and folding capacity of more than 500 times.

Q: What are the results of the antibacterial activity test?

A: The results of the antibacterial activity test show that Gotu kola leaf extract with a concentration of 10% shows the largest inhibition zone with a diameter of 11.3 mm. Meanwhile, the patch preparation from Gotu kola extract shows the maximum inhibitory zone in the F5 formulation with a diameter of 9.80 mm.

Q: Is the patch preparation formulation safe to use?

A: The patch preparation formulation has been shown to be safe to use, with no adverse effects reported in the study. However, further studies are needed to fully understand its effects and to determine its long-term safety.

Q: Can the patch preparation formulation be used to treat other skin conditions?

A: While the patch preparation formulation has been shown to be effective in treating acne, it may also be effective in treating other skin conditions such as wounds, cuts, and scrapes. However, further studies are needed to determine its effectiveness in treating these conditions.

Q: Where can I buy the patch preparation formulation?

A: The patch preparation formulation is not yet commercially available. However, it may be available in the future as a prescription medication or over-the-counter treatment.

Q: Can I make the patch preparation formulation at home?

A: While it is possible to make the patch preparation formulation at home, it is not recommended. The formulation requires specialized equipment and expertise to produce, and making it at home may not result in a safe and effective product.

Q: What are the potential side effects of the patch preparation formulation?

A: While the patch preparation formulation has been shown to be safe to use, there may be potential side effects such as skin irritation, allergic reactions, and other adverse effects. However, these side effects are rare and may be minimized by following the instructions for use carefully.

Q: Can I use the patch preparation formulation if I am pregnant or breastfeeding?

A: While the patch preparation formulation has been shown to be safe to use, it is not recommended for use during pregnancy or breastfeeding. Further studies are needed to determine its safety in these populations.

Q: How long does the patch preparation formulation take to work?

A: The patch preparation formulation may take several days to several weeks to work, depending on the severity of the acne and the individual's response to the treatment.

Q: Can I use the patch preparation formulation in combination with other acne treatments?

A: While the patch preparation formulation may be used in combination with other acne treatments, it is not recommended. Further studies are needed to determine its safety and effectiveness when used in combination with other treatments.