The Importance of Contraceptive Drugs with a Combination of Methanol Extract of Bitter Melon and DMPA

Oct 13, 2025 by wbrum.org 64 views

The Effect of a Combination of Methanol Extract of Bitter Melon (Momordica Charantia L.) and the Medroxiprogesterone Acetate Depot (DMPA) on Pancreatic Histology and Male Rabbit Blood Sugar Levels

Introduction

The development of contraceptive drugs with a combination of methanol extract of bitter melon (Momordica Charantia L.) and the Medroxyprogesterone acetate (DMPA) depot is an interesting and relevant research topic at this time. DMPA, which is a form of hormonal contraception, contains steroids and is anti-insulin. The use of DMPA can affect the body weight and blood sugar levels of its users. On the other hand, bitter melon seeds are known to have compounds that can reduce blood sugar levels, which make this combination worthy of further investigation.

The Importance of Contraceptive Drugs with a Combination of Methanol Extract of Bitter Melon and DMPA

Contraceptive drugs are essential for preventing unwanted pregnancies and providing women with reproductive autonomy. However, the side effects of hormonal contraceptives, such as DMPA, can be significant, including weight gain and changes in blood sugar levels. The combination of methanol extract of bitter melon and DMPA may offer a safer and more effective alternative for controlling body weight and blood sugar levels.

Research Purposes

This study aims to determine the effect of a combination of methanol extracts of bitter melon and DMPA seeds on pancreatic histology and male rabbit blood sugar levels. In this study, the method used was a complete random design (RAL) with five treatment groups based on different observations. Each group consists of control groups and treatment groups, including observations on 0 weeks (K0 and P0), 4 weeks (K1 and P1), 8 weeks (K2 and P2), 12 weeks (K3 and P3), and 16 weeks (K4 and P4).

Research Methodology

All rabbits in the treatment group are induced by DMPA on the first day of the study, then given methanol extract of bitter melon at a dose of 390 mg/1.5 kg body weight every day during the treatment period. Conversely, the control group is not induced by DMPA, but is given 1 ml of distilled water every day. For groups that were observed for 12 and 16 weeks, both the treatment group and control were only given extracts for 8 weeks and then maintained without additional treatment.

Theoretical Background

DMPA is a form of hormonal contraception that contains steroids and is anti-insulin. The use of DMPA can affect the body weight and blood sugar levels of its users. On the other hand, bitter melon seeds are known to have compounds that can reduce blood sugar levels. The combination of methanol extract of bitter melon and DMPA may offer a safer and more effective alternative for controlling body weight and blood sugar levels.

Hypothesis

It is hypothesized that the combination of methanol extract of bitter melon and DMPA seeds will not produce significant changes in body weight and blood sugar levels in the entire group. This hypothesis is based on the fact that bitter melon seeds have compounds that can reduce blood sugar levels, which may counteract the effects of DMPA on blood sugar levels.

Results and Analysis

The results showed that the combination of methanol extract of bitter melon and DMPA seeds did not produce significant changes in body weight and blood sugar levels in the entire group. This indicates that this combination may have the potential as a safe and effective drug for controlling body weight and blood sugar levels. However, this result raises further questions about the mechanism of work of the combination, especially in its influence on the histology of the pancreas.

However, the influence on the pancreas histology cannot be clearly determined in this study, due to difficulties in obtaining pancreas incisions that are in accordance with the standards needed for detailed histological analysis. This underlines the importance of better techniques in taking and processing samples to get more accurate results.

Conclusion

From the results of this study, it can be concluded that the combination of methanol extract of bitter melon and DMPA seeds does not show a significant impact on body weight and male rabbit blood sugar levels. This provides hope for the use of this combination in the development of safe contraceptive drugs. However, further research needs to be carried out to explore the effect of this combination on pancreas histology and its mechanism. Further research is also expected to overcome the difficulties faced in histology analysis to get more valid and useful results.

Recommendations

Based on the results of this study, the following recommendations are made:

Further research is needed to explore the effect of the combination of methanol extract of bitter melon and DMPA seeds on pancreas histology and its mechanism.
Better techniques in taking and processing samples are needed to get more accurate results in histology analysis.
The combination of methanol extract of bitter melon and DMPA seeds may have potential as a safe and effective drug for controlling body weight and blood sugar levels.

Limitations of the Study

This study has several limitations, including:

The study was conducted on male rabbits, which may not be representative of human subjects.
The study was conducted for a short period of time, which may not be sufficient to determine the long-term effects of the combination of methanol extract of bitter melon and DMPA seeds.
The study did not control for other factors that may affect body weight and blood sugar levels, such as diet and exercise.

Future Directions

Future studies should aim to overcome the limitations of this study by:

Conducting the study on human subjects.
Conducting the study for a longer period of time to determine the long-term effects of the combination of methanol extract of bitter melon and DMPA seeds.
Controlling for other factors that may affect body weight and blood sugar levels, such as diet and exercise.

Conclusion

In conclusion, this study provides hope for the use of the combination of methanol extract of bitter melon and DMPA seeds in the development of safe contraceptive drugs. However, further research is needed to explore the effect of this combination on pancreas histology and its mechanism. Further research is also expected to overcome the difficulties faced in histology analysis to get more valid and useful results.
Q&A: The Effect of a Combination of Methanol Extract of Bitter Melon (Momordica Charantia L.) and the Medroxiprogesterone Acetate Depot (DMPA) on Pancreatic Histology and Male Rabbit Blood Sugar Levels

Q: What is the purpose of this study?

A: The purpose of this study is to determine the effect of a combination of methanol extracts of bitter melon and DMPA seeds on pancreatic histology and male rabbit blood sugar levels.

Q: What is the significance of this study?

A: This study is significant because it investigates the potential of a combination of methanol extract of bitter melon and DMPA seeds as a safe and effective contraceptive drug. The use of DMPA can affect the body weight and blood sugar levels of its users, and the combination of methanol extract of bitter melon and DMPA may offer a safer and more effective alternative.

Q: What are the potential benefits of this combination?

A: The potential benefits of this combination include:

Safe and effective contraception
Reduced risk of weight gain and changes in blood sugar levels
Potential for improved pancreatic histology

Q: What are the limitations of this study?

A: The limitations of this study include:

The study was conducted on male rabbits, which may not be representative of human subjects
The study was conducted for a short period of time, which may not be sufficient to determine the long-term effects of the combination of methanol extract of bitter melon and DMPA seeds
The study did not control for other factors that may affect body weight and blood sugar levels, such as diet and exercise

Q: What are the potential risks of this combination?

A: The potential risks of this combination include:

Unknown effects on human subjects
Potential for adverse effects on pancreatic histology
Potential for interactions with other medications

Q: What are the next steps in this research?

A: The next steps in this research include:

Conducting further studies on human subjects
Conducting longer-term studies to determine the effects of the combination of methanol extract of bitter melon and DMPA seeds on pancreatic histology and blood sugar levels
Investigating the potential for interactions with other medications

Q: What are the implications of this study for public health?

A: The implications of this study for public health include:

Potential for a safe and effective alternative to hormonal contraceptives
Potential for improved reproductive health outcomes
Potential for reduced risk of weight gain and changes in blood sugar levels

Q: What are the potential applications of this research?

A: The potential applications of this research include:

Development of a new contraceptive drug
Investigation of the potential for improved pancreatic histology
Investigation of the potential for reduced risk of weight gain and changes in blood sugar levels

Q: What are the potential future directions for this research?

A: The potential future directions for this research include:

Investigation of the effects of the combination of methanol extract of bitter melon and DMPA seeds on other health outcomes, such as cardiovascular disease and cancer
Investigation of the potential for this combination to be used in combination with other medications
Investigation of the potential for this combination to be used in different populations, such as women and children.