The Effect of Ethanol Extract of Live Leaf Connect on Atherosclerosis Lesions in Male White Rats Induced by Allocsan

Oct 13, 2025 by wbrum.org 82 views

The Effect of Ethanol Extract of Live Leaf Connect on Atherosclerosis Lesions in Male White Rats Induced by Allocsan

Introduction

Diabetes mellitus is a medical condition characterized by disorders in the production and supply of insulin, which results in high levels of glucose in the blood (hyperglycemia). This condition can lead to various complications, including atherosclerosis, a condition where the arteries become narrowed and hardened due to the buildup of plaque. Recent research has focused on the potential of the leaf of the life (Gynura Procumbens [Lour.] Merr.) as therapeutic agents in managing diabetes and its related complications. The live leaf extract is known to have bioactive compounds that can reduce damage to the aorta, making it a focus of research related to its atherosclerosis lesions in white rats (Rattus norvegicus L.) male induced by allocsan.

The Importance of Atherosclerosis Research

Atherosclerosis is a major risk factor for cardiovascular diseases, including heart attacks and strokes. The condition is characterized by the buildup of plaque in the arteries, which can lead to the narrowing and hardening of the arteries. This can result in reduced blood flow to the organs and tissues, leading to various complications. The development of atherosclerosis is a complex process that involves the interaction of multiple factors, including genetic, environmental, and lifestyle factors. In this study, we aimed to investigate the effect of ethanol extract of live leaf connect on atherosclerosis lesions in male white rats induced by allocsan.

Research Methodology

In this study, a complete randomized design (CRD) was used with a total of six groups, each repeated four times. The groups consisted of:

K-: without treatment
K+: Diabetes with allocsan
P1: Metformin 45 mg/kgB
P2: diabetes + extract SB 100 mg/kgBW
P3: Diabetes + Extract SB 150 mg/kgBW
P4: diabetes + extract SB 200 mg/kgBW

Diabetes mice were identified based on blood glucose levels. The aortic organs preparation process was carried out by the paraffin method and colored using hematoxylin eosin (HE).

Research Results

The results obtained show that the treatment of leaf extract of lives with a dose of 150 mg/kgBW has a positive influence on the improvement of aortic histology. The average thickness of the aortic wall increased to 76.45 μm, while the diameter of the aortic lumen reached an average of 58.79 μm. In addition, the score of atherosclerosis lesions also decreased significantly with an average value of 1.5.

Additional Analysis and Explanation

This study highlights the importance of leaf extracts of lives in the treatment of diabetes-related diseases and atherosclerosis. Bioactive compounds in this extract are likely to play a role in reducing inflammation, improving vascular health, and returning the normal function of endothelial cells that are affected by high glucose levels.

In addition, the dose of 150 mg/kgBW is proven to be the optimal dose that provides the greatest benefit in improving the thickness of the aortic wall and reduces atherosclerosis lesions. This finding can be the first step for further research related to the potential of lives in diabetes mellitus therapy and cardiovascular complications.

Conclusion

In this context, continued life is not just an herbal plant, but also has the potential as a therapeutic candidate in the management of diabetes and preventing atherosclerosis complications. Further research is needed to understand the mechanism of work of bioactive compounds in the leaf of life and its potential use in clinical practice.

Implications of the Study

The results of this study provide new hope for the development of safer and more effective diabetes therapy, as well as opening a way for deeper research in the health sector that focuses on the use of natural resources as an alternative treatment. The study highlights the potential of live leaf extract as a therapeutic agent in managing diabetes and its related complications, and provides a basis for further research in this area.

Future Directions

Further research is needed to understand the mechanism of work of bioactive compounds in the leaf of life and its potential use in clinical practice. This includes studies on the pharmacokinetics and pharmacodynamics of live leaf extract, as well as its potential interactions with other medications. Additionally, studies on the safety and efficacy of live leaf extract in humans are needed to confirm its potential as a therapeutic agent in managing diabetes and its related complications.

Limitations of the Study

This study has several limitations, including the use of a small sample size and the lack of control group. Additionally, the study was conducted in a laboratory setting, and the results may not be generalizable to humans. Further research is needed to confirm the findings of this study and to understand the potential of live leaf extract as a therapeutic agent in managing diabetes and its related complications.

Conclusion

In conclusion, this study provides new hope for the development of safer and more effective diabetes therapy, as well as opening a way for deeper research in the health sector that focuses on the use of natural resources as an alternative treatment. The study highlights the potential of live leaf extract as a therapeutic agent in managing diabetes and its related complications, and provides a basis for further research in this area.
Q&A: The Effect of Ethanol Extract of Live Leaf Connect on Atherosclerosis Lesions in Male White Rats Induced by Allocsan

Q: What is the purpose of this study?

A: The purpose of this study is to investigate the effect of ethanol extract of live leaf connect on atherosclerosis lesions in male white rats induced by allocsan. Atherosclerosis is a major risk factor for cardiovascular diseases, including heart attacks and strokes, and is characterized by the buildup of plaque in the arteries.

Q: What is the significance of this study?

A: This study highlights the potential of live leaf extract as a therapeutic agent in managing diabetes and its related complications, including atherosclerosis. The results of this study provide new hope for the development of safer and more effective diabetes therapy, as well as opening a way for deeper research in the health sector that focuses on the use of natural resources as an alternative treatment.

Q: What are the bioactive compounds in live leaf extract?

A: The bioactive compounds in live leaf extract are likely to play a role in reducing inflammation, improving vascular health, and returning the normal function of endothelial cells that are affected by high glucose levels.

Q: What is the optimal dose of live leaf extract for improving aortic histology?

A: The optimal dose of live leaf extract for improving aortic histology is 150 mg/kgBW. This dose has been shown to increase the average thickness of the aortic wall and reduce the score of atherosclerosis lesions.

Q: What are the limitations of this study?

A: This study has several limitations, including the use of a small sample size and the lack of control group. Additionally, the study was conducted in a laboratory setting, and the results may not be generalizable to humans. Further research is needed to confirm the findings of this study and to understand the potential of live leaf extract as a therapeutic agent in managing diabetes and its related complications.

Q: What are the future directions for this research?

A: Further research is needed to understand the mechanism of work of bioactive compounds in the leaf of life and its potential use in clinical practice. This includes studies on the pharmacokinetics and pharmacodynamics of live leaf extract, as well as its potential interactions with other medications. Additionally, studies on the safety and efficacy of live leaf extract in humans are needed to confirm its potential as a therapeutic agent in managing diabetes and its related complications.

Q: What are the implications of this study for the management of diabetes and its related complications?

A: The results of this study provide new hope for the development of safer and more effective diabetes therapy, as well as opening a way for deeper research in the health sector that focuses on the use of natural resources as an alternative treatment. The study highlights the potential of live leaf extract as a therapeutic agent in managing diabetes and its related complications, and provides a basis for further research in this area.

Q: What are the potential benefits of using live leaf extract as a therapeutic agent in managing diabetes and its related complications?

A: The potential benefits of using live leaf extract as a therapeutic agent in managing diabetes and its related complications include:

Reduced inflammation and improved vascular health
Improved function of endothelial cells
Reduced risk of cardiovascular disease
Improved quality of life for individuals with diabetes and its related complications

Q: What are the potential risks or side effects of using live leaf extract as a therapeutic agent in managing diabetes and its related complications?

A: The potential risks or side effects of using live leaf extract as a therapeutic agent in managing diabetes and its related complications are not well understood and require further research. However, it is possible that live leaf extract may interact with other medications or have adverse effects in certain individuals.

Q: How can individuals with diabetes and its related complications access live leaf extract as a therapeutic agent?

A: Live leaf extract is not currently available as a therapeutic agent for the management of diabetes and its related complications. However, further research is needed to understand its potential as a therapeutic agent, and it may be available in the future as a natural supplement or medication. Individuals with diabetes and its related complications should consult with their healthcare provider before using any new therapies or supplements.