The Effect of Aloe Vera Extract on Wound Healing in Terms of Oral Mucosa in White Mice

Oct 13, 2025 by wbrum.org 54 views

The Effect of Aloe Vera Extract on Wound Healing in Terms of Oral Mucosa in White Mice

Introduction

Wounds in the oral mucosa are a common issue that can be caused by various factors, including trauma, infection, or disease. The healing process of these wounds is crucial to prevent further complications and promote overall health. In recent years, there has been a growing interest in using natural ingredients as a healing solution, known as the New Green Wave. One plant that has been increasingly used as a traditional medicine to heal wounds is aloe vera (aloe vera). This plant is rich in active substances that play a role in cell regeneration and accelerate the wound healing process.

Background

Aloe vera has been used for centuries in traditional medicine to treat various health conditions, including wounds and skin irritations. The plant contains various bioactive substances, including aloin, emodine, and amino acids, which have been proven to stimulate the regeneration of epithelial cells and accelerate wound healing. In addition, aloe vera has anti-inflammatory and antioxidant properties that contribute to the wound healing process.

Methodology

This study aims to evaluate the effects of aloe vera extract on the thickness and width of the epithelial gap in the oral mucosa of white mice. The research design is a pure experiment with a post-test and control group. In this study, twenty-four male white mice from the 2-3-month-old wistar strain were divided into four groups: two groups (1 and 2) were not smeared with aloe vera extract (control groups), while the other two groups (3 and 4) were smeared aloe vera extract (treatment group). The wound is made in the oral mucosa of the left mouse with a diameter of 10 mm and a depth of 2.5 mm. Rats in groups 1 and 3 are sacrificed on the 7th day, while groups 2 and 4 on the 14th day. After that, the wound tissue is taken and made histological preparations through the coloring of hematoxylin-eosin.

Results

The results of this study showed that the independent sample t-test did not show a significant effect of aloe vera extract on epithelial thickness (P> 0.05). However, the Mann Whitney test results showed a significant effect of aloe vera extract on the width of the epithelial gap (p <0.05). This indicates that aloe vera extract has the ability to accelerate the formation of epithelial thickness and wound closure of the oral mucosa.

Discussion

The results of this study show the importance of using aloe vera in the treatment of wounds, especially in the context of dentistry. Although the positive effect on the thickness of the epithelium does not look significant, the effect on the width of the epithelial gap indicates that aloe vera extract can help speed up wound healing by reducing the size of the gap formed. The use of aloe vera extract is expected to be a safe and effective alternative therapy, considering that more people tend to look for natural-based solutions.

Conclusion

In conclusion, this study has shown that aloe vera extract has a significant effect on the width of the epithelial gap in the oral mucosa of white mice. This indicates that aloe vera extract can help speed up wound healing by reducing the size of the gap formed. The use of aloe vera extract is expected to be a safe and effective alternative therapy, considering that more people tend to look for natural-based solutions. Further research is needed to explore the potential of aloe vera in modern medicine and to develop the right formulation for its use in wound healing.

Recommendations

Based on the results of this study, the following recommendations are made:

Further research is needed to explore the potential of aloe vera in modern medicine.
The development of the right formulation for the use of aloe vera in wound healing is necessary.
Medical practitioners should continue to explore and understand the potential of natural ingredients such as aloe vera in modern medicine.
The use of proper natural therapy can not only improve the quality of healing, but also reduces dependence on chemical drugs that often have side effects.

Limitations

This study has several limitations, including:

The sample size was small, and further research is needed to confirm the results.
The study was conducted on white mice, and further research is needed to explore the effects of aloe vera extract on humans.
The study only evaluated the effects of aloe vera extract on the width of the epithelial gap, and further research is needed to explore its effects on other aspects of wound healing.

Future Directions

Future research should focus on exploring the potential of aloe vera in modern medicine, including its effects on wound healing, skin health, and other health conditions. Additionally, further research is needed to develop the right formulation for the use of aloe vera in wound healing and to explore its effects on humans.

References

[List of references cited in the study]

Appendix

[Appendix materials, including raw data, figures, and tables]

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Frequently Asked Questions (FAQs) about Aloe Vera and Wound Healing

Q: What is aloe vera and how does it help with wound healing?

A: Aloe vera is a plant that has been used for centuries in traditional medicine to treat various health conditions, including wounds and skin irritations. It contains various bioactive substances, including aloin, emodine, and amino acids, which have been proven to stimulate the regeneration of epithelial cells and accelerate wound healing.

Q: What are the benefits of using aloe vera for wound healing?

A: Aloe vera has several benefits for wound healing, including:

Stimulating the regeneration of epithelial cells
Accelerating wound healing
Reducing inflammation and pain
Promoting tissue repair and regeneration
Improving skin health and appearance

Q: Can aloe vera be used to treat all types of wounds?

A: Aloe vera can be used to treat various types of wounds, including minor cuts and scrapes, burns, and surgical wounds. However, it is not recommended for use on deep or infected wounds, as it may not be effective in promoting healing.

Q: How do I use aloe vera for wound healing?

A: Aloe vera can be applied topically to the wound area using a gel or cream. It is recommended to apply a thin layer of aloe vera gel to the wound area 2-3 times a day, and to cover the wound with a bandage or dressing.

Q: Are there any side effects of using aloe vera for wound healing?

A: Aloe vera is generally considered safe for use on wounds, but it may cause some side effects, including:

Allergic reactions
Skin irritation
Burning or stinging sensation
Increased risk of infection

Q: Can aloe vera be used in combination with other treatments for wound healing?

A: Yes, aloe vera can be used in combination with other treatments for wound healing, including antibiotics, antiseptics, and dressings. However, it is recommended to consult with a healthcare professional before using aloe vera in combination with other treatments.

Q: How long does it take for aloe vera to work on wounds?

A: The time it takes for aloe vera to work on wounds can vary depending on the severity and type of wound. However, aloe vera can start to show its effects within 24-48 hours of application, and can continue to promote healing for several days or weeks.

Q: Can aloe vera be used on children and pregnant women?

A: Aloe vera can be used on children and pregnant women, but it is recommended to consult with a healthcare professional before using it on these populations. Aloe vera is generally considered safe for use on children and pregnant women, but it may cause some side effects, including allergic reactions and skin irritation.

Q: Where can I buy aloe vera for wound healing?

A: Aloe vera can be purchased at various health food stores, pharmacies, and online retailers. It is recommended to choose a high-quality aloe vera product that is free of additives and preservatives.

Q: How do I store aloe vera for wound healing?

A: Aloe vera should be stored in a cool, dry place, away from direct sunlight and heat. It is recommended to store aloe vera in an airtight container to prevent spoilage and contamination.

Q: Can aloe vera be used on animals?

A: Aloe vera can be used on animals, but it is recommended to consult with a veterinarian before using it on pets. Aloe vera can be used to treat various health conditions in animals, including skin irritations, wounds, and allergies.

Q: Are there any contraindications for using aloe vera for wound healing?

A: Yes, there are several contraindications for using aloe vera for wound healing, including:

Allergic reactions to aloe vera
Skin irritation or sensitivity
Open wounds or cuts
Deep or infected wounds
Pregnant or breastfeeding women
Children under the age of 6

It is recommended to consult with a healthcare professional before using aloe vera for wound healing, especially if you have any underlying medical conditions or are taking any medications.