Further research is needed to explore the potential of NLR and HSCRP as a biomarker for acute ischemic stroke

Oct 13, 2025 by wbrum.org 2 views

Relationship of Lymphocyte Neutrophil Ratio and High Sensitivity C-Reactive Protein with the Severity and Outcome in Acute Ischemic Stroke Patients

Acute ischemic stroke is a serious medical condition that occurs when blood flow to the brain is interrupted, leading to brain damage and various symptoms such as weakness, difficulty speaking, and vision problems. Inflammation plays a crucial role in the pathophysiology of acute ischemic stroke, triggering secondary brain damage and worsening the patient's condition. Understanding the relationship between inflammatory markers and the severity and outcome of acute ischemic stroke is essential for developing effective treatment strategies.

The Role of Inflammation in Acute Ischemic Stroke

Inflammation is a complex biological response that occurs in response to tissue damage or infection. In the context of acute ischemic stroke, inflammation can exacerbate brain damage and worsen the patient's condition. Lymphocyte Neutrophil Ratio (NLR) and High Sensitivity C-Reactive Protein (HSCRP) are two inflammatory markers that have been shown to play a significant role in the pathophysiology of acute ischemic stroke.

Lymphocyte Neutrophil Ratio (NLR)

NLR is a marker of systemic inflammation that reflects the balance between lymphocytes and neutrophils in the blood. A high NLR indicates an increased inflammatory response, which can lead to secondary brain damage and worsen the patient's condition. Research has shown that NLR is a predictor of poor outcomes in patients with acute ischemic stroke.

High Sensitivity C-Reactive Protein (HSCRP)

HSCRP is a marker of inflammation that is produced in response to tissue damage or infection. A high HSCRP level indicates an increased inflammatory response, which can lead to secondary brain damage and worsen the patient's condition. Research has shown that HSCRP is a predictor of poor outcomes in patients with acute ischemic stroke.

The Relationship between NLR, HSCRP, and Acute Ischemic Stroke

This study aimed to examine the relationship between NLR, HSCRP, and the severity and outcome of acute ischemic stroke patients. The results showed a significant positive correlation between NLR and HSCRP with the severity and outcome of acute ischemic stroke. The study found that patients with high NLR and HSCRP levels had a higher severity of stroke and worse outcomes.

Research Methods

This study used a latitude cutting design by involving 38 acute ischemic stroke patients at the Adam Malik Hajj Center General Hospital in Medan. Data collection was carried out on the first day the patient was treated. NLR and HSCRP were measured on the first day. The severity of stroke was considered using the National Institutes of Health Stroke Scale (NIHSS), while outcomes were considered using the Modified Rankin Scale (MRS) on the first and 14th days. Data analysis used the contingency and gamma coefficient correlation test.

Research Results

Demographic characteristics of patients showed an average age of 62 years, with the highest level of education being high school graduates, and most patients not working. The results showed a significant positive correlation between NLR and HSCRP with the severity and acute ischemic outcome stroke.

*** NLR and Severity: ** Positive correlation with medium strength (r = 0.511; p = 0.001) shows that the higher the NLR, the higher the severity of the stroke. *** NLR and Outcome: ** Positive correlation with moderate strength (r = 0.463; p = 0.001) indicates that patients with high NLR tend to have worse outcomes. *** HSCRP and Severity: ** Positive correlation with very strong strength (r = 0.896; p = 0.001) shows a strong relationship between HSCRP level and stroke severity. *** HSCRP and Outcome: ** Positive correlation with strong strength (r = 0.624; p = 0.001) indicates that high HSCRP is related to worse outcome stroke.

Conclusion

This study shows a positive and significant relationship between NLR and HSCRP with severity and outcome in acute ischemic stroke patients. These findings indicate that NLR and HSCRP can be a potential biomarker in predicting the severity and outcome in acute ischemic stroke patients.

Additional Analysis

The results of this study are consistent with various previous studies that show the role of inflammation in the pathophysiology of acute ischemic stroke. NLR and HSCRP are inflammatory markers that reflect immune system activity in responding to brain injury. The high value of NLR and HSCRP shows an increase in inflammatory activity which can cause secondary brain damage and worsen the patient's condition.

Recommendation

Further research by involving a larger number of samples and longitudinal design is needed to confirm this finding and explore the potential of NLR and HSCRP as a prediction marker and intervention target in acute ischemic stroke patients.

Implications for Clinical Practice

The findings of this study have significant implications for clinical practice. Early identification of patients with high NLR and HSCRP levels can help clinicians to predict the severity and outcome of acute ischemic stroke. This can enable clinicians to provide targeted interventions and improve patient outcomes. Further research is needed to explore the potential of NLR and HSCRP as a biomarker for acute ischemic stroke.

Limitations of the Study

This study has several limitations. The sample size was small, and the study was conducted in a single hospital. Further research is needed to confirm the findings of this study and explore the generalizability of the results. The study did not control for potential confounding variables, such as age and sex. Further research is needed to explore the relationship between NLR, HSCRP, and acute ischemic stroke in different populations.

Future Directions

This study provides a foundation for further research on the relationship between NLR, HSCRP, and acute ischemic stroke. Future studies should aim to confirm the findings of this study and explore the potential of NLR and HSCRP as a biomarker for acute ischemic stroke. Further research is needed to explore the mechanisms underlying the relationship between NLR, HSCRP, and acute ischemic stroke.
Frequently Asked Questions (FAQs) about the Relationship between Lymphocyte Neutrophil Ratio and High Sensitivity C-Reactive Protein with the Severity and Outcome in Acute Ischemic Stroke Patients

Q: What is the relationship between lymphocyte neutrophil ratio (NLR) and high sensitivity C-reactive protein (HSCRP) with the severity and outcome in acute ischemic stroke patients?

A: This study found a significant positive correlation between NLR and HSCRP with the severity and outcome in acute ischemic stroke patients. The results showed that patients with high NLR and HSCRP levels had a higher severity of stroke and worse outcomes.

Q: What is the significance of NLR and HSCRP in acute ischemic stroke?

A: NLR and HSCRP are inflammatory markers that reflect immune system activity in responding to brain injury. The high value of NLR and HSCRP shows an increase in inflammatory activity which can cause secondary brain damage and worsen the patient's condition.

Q: How can NLR and HSCRP be used as biomarkers for acute ischemic stroke?

A: Early identification of patients with high NLR and HSCRP levels can help clinicians to predict the severity and outcome of acute ischemic stroke. This can enable clinicians to provide targeted interventions and improve patient outcomes.

Q: What are the limitations of this study?

A: The sample size was small, and the study was conducted in a single hospital. Further research is needed to confirm the findings of this study and explore the generalizability of the results. The study did not control for potential confounding variables, such as age and sex.

Q: What are the implications of this study for clinical practice?

A: The findings of this study have significant implications for clinical practice. Early identification of patients with high NLR and HSCRP levels can help clinicians to predict the severity and outcome of acute ischemic stroke. This can enable clinicians to provide targeted interventions and improve patient outcomes.

Q: What are the future directions for research on the relationship between NLR, HSCRP, and acute ischemic stroke?

A: Further research is needed to confirm the findings of this study and explore the potential of NLR and HSCRP as a biomarker for acute ischemic stroke. Further research is also needed to explore the mechanisms underlying the relationship between NLR, HSCRP, and acute ischemic stroke.

Q: Can NLR and HSCRP be used to predict the outcome of acute ischemic stroke?

A: Yes, the results of this study suggest that NLR and HSCRP can be used to predict the outcome of acute ischemic stroke. Patients with high NLR and HSCRP levels had a higher severity of stroke and worse outcomes.

Q: What are the potential benefits of using NLR and HSCRP as biomarkers for acute ischemic stroke?

A: The potential benefits of using NLR and HSCRP as biomarkers for acute ischemic stroke include early identification of patients at risk, targeted interventions, and improved patient outcomes.

Q: What are the potential limitations of using NLR and HSCRP as biomarkers for acute ischemic stroke?

A: The potential limitations of using NLR and HSCRP as biomarkers for acute ischemic stroke include the need for further research to confirm the findings of this study and explore the generalizability of the results. Additionally, the study did not control for potential confounding variables, such as age and sex.

Q: Can NLR and HSCRP be used to predict the severity of acute ischemic stroke?

A: Yes, the results of this study suggest that NLR and HSCRP can be used to predict the severity of acute ischemic stroke. Patients with high NLR and HSCRP levels had a higher severity of stroke.

Q: What are the potential applications of using NLR and HSCRP as biomarkers for acute ischemic stroke?

A: The potential applications of using NLR and HSCRP as biomarkers for acute ischemic stroke include early identification of patients at risk, targeted interventions, and improved patient outcomes. Additionally, NLR and HSCRP can be used to monitor the effectiveness of treatment and predict the outcome of acute ischemic stroke.