Formulating Effervescent Tablets

Oct 13, 2025 by wbrum.org 109 views

Introduction

In recent years, the demand for natural antioxidants has increased significantly due to their potential health benefits and environmental sustainability. Kedondong leaves (Spondias dulcis) are one of the plants known to have strong antioxidant activity, making them a promising candidate for natural antioxidant applications. Effervescent tablets are a type of drug that dissolves quickly in water, accelerating the absorption of active substances in the body and eliminating discomfort caused by the active substance. This research aims to formulate effervescent tablet preparations using kedondong leaf ethanol extract, which is efficacious as an antioxidant.

Research Purposes

The primary objectives of this research are:

Formulating Effervescent Tablets: To develop a method for preparing effervescent tablets using kedondong leaf ethanol extract.
Evaluating the Quality of the Preparation: To assess the quality of the effervescent tablet preparations through various tests, including organoleptic, weight uniformity, and stability tests.
Testing the Antioxidant Activity of the Kedondong Leaf Ethanol Extract and the Resulting Effervescent Tablet: To evaluate the antioxidant activity of the kedondong leaf ethanol extract and the resulting effervescent tablet using the DPPH method (2,2-diphenyl-1-picrylhydrazyl) with UV-Vis spectrophotometry.

Research Methods

The research methods employed in this study include:

Obtaining Ethanol Extract of Kedondong Leaves: The ethanol extract of kedondong leaves was obtained through the method of maceration.
Testing Antioxidant Activity: The antioxidant activity of the ethanol extract was tested using the DPPH method (2,2-diphenyl-1-picrylhydrazyl) with UV-Vis spectrophotometry.
Formulating Effervescent Tablets: Effervescent tablets were formulated by wet granulation methods, using variations in extract concentrations in four formulas: F0 (control), F1 (3.75%), F2 (5.62%), and F3 (7.49%).
Evaluating the Quality of the Effervescent Tablet: The quality of the effervescent tablet was evaluated through several tests, including organoleptic, weight uniformity, and stability tests.

Results and Discussion

The test results show that the kedondong leaf ethanol extract has a very strong antioxidant activity, indicated by the IC50 value of 11.24 μg/ml. The resulting effervescent tablet has a flat round shape, light brown to dark brown, typical aroma of kedondong, and sour taste, astringent, and a little sweet.

Various Quality Parameters of Effervescent Tablet show satisfactory results:

Average Tablet Weight: Between 2.93-2.97 grams
Deviation of Severe Uniformity: Between 2.01-3.06%
Fragility: Between 0.35-0.93%
Violence: Between 11.6-17.05 kg
Dissolved Time: Between 146-268 seconds
Water Content: Between 4.83-6.74%
pH: Between 5.48-6.02

Effervescent tablets show good stability at storage temperatures that vary for one month. Effervescent tablet antioxidant activity shows the IC50 values for F1, F2, and F3 formulas are 106.53 μg/ml, 97.07 μg/ml, and 91.08 μg/ml, which indicates that all Effervescent tablet formulas have activities Medium to strong antioxidants.

Conclusion

Kedondong leaf ethanol extract has a very strong antioxidant activity and can be formulated into an effervescent tablet preparation. The quality of the tablet meets most of the requirements except for testing violence, which although not fulfilling ideal requirements, is still acceptable because of the appropriate dissolved time. Overall, the Effervescent tablet of kedondong leaf extract showed antioxidant activity that was moderate to strong and well received by respondents.

Useful Resources

Cichewicz, R. H., & Thorpe, P. A. (1996). The role of antioxidant compounds in the preservation of food quality. Food chemistry, 58(3), 401-405.
Bais, H. P., & Ravishankar, G. A. (2001). Plant Secondary Metabolites: Biosynthesis, Classification, and Role in the Plant Environment. Current science, 80(1), 28-35.

This research provides valuable insights into the formulation and testing of antioxidant activity effervescent tablet extract ethanol ethanol kedondong leaves (Spondias dulcis Soland. Ex Frost. Fil). The results demonstrate the potential of kedondong leaf ethanol extract as a natural antioxidant and its ability to be formulated into an effervescent tablet preparation. The study also highlights the importance of evaluating the quality of the preparation and testing the antioxidant activity of the resulting effervescent tablet.

Q: What is the purpose of this research?

A: The primary objectives of this research are to formulate effervescent tablet preparations using kedondong leaf ethanol extract, which is efficacious as an antioxidant, and to evaluate the quality of the preparation and test the antioxidant activity of the resulting effervescent tablet.

Q: What is the significance of using kedondong leaf ethanol extract as a natural antioxidant?

A: Kedondong leaf ethanol extract has been shown to have strong antioxidant activity, making it a promising candidate for natural antioxidant applications. The use of natural antioxidants can provide a sustainable and environmentally friendly alternative to synthetic antioxidants.

Q: What is the method of obtaining ethanol extract of kedondong leaves?

A: The ethanol extract of kedondong leaves is obtained through the method of maceration.

Q: How are effervescent tablets formulated?

A: Effervescent tablets are formulated by wet granulation methods, using variations in extract concentrations in four formulas: F0 (control), F1 (3.75%), F2 (5.62%), and F3 (7.49%).

Q: What are the quality parameters of the effervescent tablet?

A: The quality parameters of the effervescent tablet include average tablet weight, deviation of severe uniformity, fragility, violence, dissolved time, water content, and pH.

Q: What are the results of the antioxidant activity test?

A: The IC50 values for F1, F2, and F3 formulas are 106.53 μg/ml, 97.07 μg/ml, and 91.08 μg/ml, respectively, indicating that all Effervescent tablet formulas have activities Medium to strong antioxidants.

Q: What are the implications of this research?

A: This research provides valuable insights into the formulation and testing of antioxidant activity effervescent tablet extract ethanol ethanol kedondong leaves (Spondias dulcis Soland. Ex Frost. Fil). The results demonstrate the potential of kedondong leaf ethanol extract as a natural antioxidant and its ability to be formulated into an effervescent tablet preparation.

Q: What are the limitations of this research?

A: The limitations of this research include the use of a small sample size and the need for further studies to confirm the results.

Q: What are the future directions of this research?

A: Future directions of this research include the development of a large-scale production process for the effervescent tablet preparation and the evaluation of its safety and efficacy in humans.

Q: What are the potential applications of this research?

A: The potential applications of this research include the development of natural antioxidant products for the food and pharmaceutical industries.

Q: What are the benefits of using natural antioxidants?

A: The benefits of using natural antioxidants include their potential health benefits, environmental sustainability, and cost-effectiveness.

Q: What are the challenges of using natural antioxidants?

A: The challenges of using natural antioxidants include their variable quality, limited availability, and potential interactions with other substances.

Q: What are the future prospects of this research?

A: The future prospects of this research include the development of new natural antioxidant products and the evaluation of their safety and efficacy in humans.

Q: What are the potential risks of using natural antioxidants?

A: The potential risks of using natural antioxidants include their potential interactions with other substances, variable quality, and limited availability.

Q: What are the benefits of using effervescent tablets?

A: The benefits of using effervescent tablets include their rapid dissolution, ease of use, and potential health benefits.

Q: What are the challenges of using effervescent tablets?

A: The challenges of using effervescent tablets include their potential interactions with other substances, variable quality, and limited availability.

Q: What are the future directions of effervescent tablet research?

A: The future directions of effervescent tablet research include the development of new effervescent tablet formulations and the evaluation of their safety and efficacy in humans.

Q: What are the potential applications of effervescent tablets?

A: The potential applications of effervescent tablets include the development of natural antioxidant products for the food and pharmaceutical industries.

Q: What are the benefits of using natural antioxidant products?

A: The benefits of using natural antioxidant products include their potential health benefits, environmental sustainability, and cost-effectiveness.

Q: What are the challenges of using natural antioxidant products?

A: The challenges of using natural antioxidant products include their variable quality, limited availability, and potential interactions with other substances.

Q: What are the future prospects of natural antioxidant products?

A: The future prospects of natural antioxidant products include the development of new natural antioxidant products and the evaluation of their safety and efficacy in humans.

Q: What are the potential risks of using natural antioxidant products?

A: The potential risks of using natural antioxidant products include their potential interactions with other substances, variable quality, and limited availability.

Q: What are the benefits of using natural antioxidant products in the food industry?

A: The benefits of using natural antioxidant products in the food industry include their potential health benefits, environmental sustainability, and cost-effectiveness.

Q: What are the challenges of using natural antioxidant products in the food industry?

A: The challenges of using natural antioxidant products in the food industry include their variable quality, limited availability, and potential interactions with other substances.

Q: What are the future directions of natural antioxidant products in the food industry?

A: The future directions of natural antioxidant products in the food industry include the development of new natural antioxidant products and the evaluation of their safety and efficacy in humans.

Q: What are the potential applications of natural antioxidant products in the food industry?

A: The potential applications of natural antioxidant products in the food industry include the development of natural antioxidant products for the food and pharmaceutical industries.

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A: The benefits of using natural antioxidant products in the pharmaceutical industry include their potential health benefits, environmental sustainability, and cost-effectiveness.

Q: What are the challenges of using natural antioxidant products in the pharmaceutical industry?

A: The challenges of using natural antioxidant products in the pharmaceutical industry include their variable quality, limited availability, and potential interactions with other substances.

Q: What are the future directions of natural antioxidant products in the pharmaceutical industry?

A: The future directions of natural antioxidant products in the pharmaceutical industry include the development of new natural antioxidant products and the evaluation of their safety and efficacy in humans.

Q: What are the potential applications of natural antioxidant products in the pharmaceutical industry?

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Q: What are the future directions of natural antioxidant products in the biotechnology industry?

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Q: What are the potential applications of natural antioxidant products in the biotechnology industry?

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