Effectiveness of Drops Combination of Sand Sea Cucumber Extracts and Dragon Fruit Skin in Oral Mucositis Due to Chemotherapy

Oct 13, 2025 by wbrum.org 96 views

Effectiveness of Drops Combination of Sand Sea Cucumber Extracts and Dragon Fruit Skin in Oral Mucositis Due to Chemotherapy

Chemotherapy is a common treatment method used to combat leukemia, particularly in children. However, this therapy often comes with unpleasant side effects, one of which is oral mucositis. Mucositis is an inflammation of the mucosal tissue in the mouth, causing pain and difficulty in eating and speaking. Therefore, it is essential to find a treatment that can accelerate the healing of this mucositis. In this study, natural ingredients with potential as a component of the drug, namely sea cucumbers (Holothuria scabra) and dragon fruit skin (hylocereus polyrhizus), were used to create a combination of drops.

The Importance of Natural Ingredients in Oral Mucositis Treatment

Oral mucositis is a significant concern for patients undergoing chemotherapy, as it can lead to severe pain, difficulty in eating, and speaking. Conventional treatments often rely on synthetic medications, which can have adverse effects on the body. In contrast, natural ingredients like sea cucumbers and dragon fruit skin have been shown to possess anti-inflammatory and antioxidant properties, making them potential alternatives for conventional treatment.

Sea Cucumber Extracts: A Natural Regenerative Agent

Sea cucumbers (Holothuria scabra) contain active compounds such as flavonoids, saponins, triterpenoids, alkaloids, tannins, and collagen, which have the ability to regenerate tissue. These compounds have been shown to promote wound healing, reduce inflammation, and improve tissue regeneration. The use of sea cucumber extracts in oral mucositis treatment has the potential to accelerate the healing process, reducing the severity of symptoms and improving the quality of life for patients.

Dragon Fruit Skin: A Rich Source of Natural Antioxidants

Dragon fruit skin is known to be rich in natural antioxidants, which play a crucial role in reducing oxidative stress and inflammation. Antioxidants have been shown to promote tissue repair, reduce pain, and improve overall health. The use of dragon fruit skin in oral mucositis treatment has the potential to reduce the severity of symptoms, improve tissue regeneration, and promote overall health.

Research Purposes and Methodology

This study aims to analyze the effectiveness of the combination of sand and dragon fruit sea cucumber combinations with a concentration of 20% and 40%, compared to negative control and positive control, in accelerating the healing of oral mucositis induced by chemotherapy drugs in trial mice. The research is an experimental study in vivo conducted on male wistar rats (Rattus norvegicus) with post-test control groups. A total of 36 mice are divided into four treatment groups: groups that receive combination drops with a concentration of 20% and 40%, positive control groups use hyaluronic acid gengigel, and negative control groups that are not given treatment. The mucositis healing process was clinically observed and histopathological on the 3rd, 7th, and 14th days.

Data Analysis and Results

Data analysis was carried out using the Kruskal-Wallis and Post-Hoc (Mann-Whitney) test with a significance level of P <0.05. The results showed that the combination of sand cucumber combinations and dragon fruit skin with a concentration of 20% and 40% had an equivalent effectiveness in accelerating the healing of mucositis induced by chemotherapy drugs, and gave better results compared to positive controls on observations on the day of the day 7.

Conclusion and Future Directions

From this study, it can be concluded that the combination of sand cucumber combination drugs and dragon fruit skin with a concentration of 20% is an efficient choice as a drug to accelerate the healing of oral mucositis induced by chemotherapy. The use of natural ingredients is not only effective but also environmentally friendly and can be an alternative for conventional treatment that exists today. Thus, further research needs to be done to explore other therapeutic potential of these natural ingredients in the treatment of various medical conditions.

Implications and Future Research Directions

The results of this study provide new hope for people with oral mucositis due to chemotherapy, especially children, to get a safer and more effective treatment solution. Further research is needed to explore the therapeutic potential of sea cucumber extracts and dragon fruit skin in the treatment of various medical conditions. Additionally, the development of a commercial product using these natural ingredients could provide a safer and more effective treatment option for patients with oral mucositis.

Limitations and Future Directions

This study has several limitations, including the small sample size and the use of a specific type of sea cucumber extract. Future studies should aim to increase the sample size and use different types of sea cucumber extracts to confirm the results. Additionally, the study should be replicated in humans to confirm the effectiveness of the combination of sand cucumber combinations and dragon fruit skin in accelerating the healing of oral mucositis.

Conclusion

In conclusion, the combination of sand cucumber combination drugs and dragon fruit skin with a concentration of 20% is an efficient choice as a drug to accelerate the healing of oral mucositis induced by chemotherapy. The use of natural ingredients is not only effective but also environmentally friendly and can be an alternative for conventional treatment that exists today. Further research is needed to explore other therapeutic potential of these natural ingredients in the treatment of various medical conditions.
Q&A: Drops Combination of Sand Sea Cucumber Extracts and Dragon Fruit Skin in Oral Mucositis Due to Chemotherapy

Q: What is oral mucositis and how common is it in patients undergoing chemotherapy?

A: Oral mucositis is an inflammation of the mucosal tissue in the mouth, causing pain and difficulty in eating and speaking. It is a common side effect of chemotherapy, affecting up to 90% of patients undergoing treatment.

Q: What are the current treatment options for oral mucositis?

A: Current treatment options for oral mucositis include pain management medications, antibiotics, and topical treatments such as mouthwashes and gels. However, these treatments often have limited effectiveness and can have adverse effects on the body.

Q: What are the benefits of using natural ingredients like sea cucumbers and dragon fruit skin in oral mucositis treatment?

A: Natural ingredients like sea cucumbers and dragon fruit skin have anti-inflammatory and antioxidant properties, making them potential alternatives for conventional treatment. They are also environmentally friendly and can be an alternative for conventional treatment that exists today.

Q: What are the active compounds found in sea cucumbers and how do they help in oral mucositis treatment?

A: Sea cucumbers contain active compounds such as flavonoids, saponins, triterpenoids, alkaloids, tannins, and collagen, which have the ability to regenerate tissue. These compounds have been shown to promote wound healing, reduce inflammation, and improve tissue regeneration.

Q: What are the benefits of using dragon fruit skin in oral mucositis treatment?

A: Dragon fruit skin is rich in natural antioxidants, which play a crucial role in reducing oxidative stress and inflammation. Antioxidants have been shown to promote tissue repair, reduce pain, and improve overall health.

Q: How was the combination of sand cucumber combinations and dragon fruit skin tested in this study?

A: The study used an experimental design in vivo, where male wistar rats (Rattus norvegicus) were divided into four treatment groups: groups that receive combination drops with a concentration of 20% and 40%, positive control groups use hyaluronic acid gengigel, and negative control groups that are not given treatment. The mucositis healing process was clinically observed and histopathological on the 3rd, 7th, and 14th days.

Q: What were the results of the study and what do they mean for oral mucositis treatment?

A: The results showed that the combination of sand cucumber combinations and dragon fruit skin with a concentration of 20% and 40% had an equivalent effectiveness in accelerating the healing of mucositis induced by chemotherapy drugs, and gave better results compared to positive controls on observations on the day of the day 7. This suggests that the combination of natural ingredients may be a safer and more effective treatment option for patients with oral mucositis.

Q: What are the implications of this study for future research and treatment options?

A: The results of this study provide new hope for people with oral mucositis due to chemotherapy, especially children, to get a safer and more effective treatment solution. Further research is needed to explore the therapeutic potential of sea cucumber extracts and dragon fruit skin in the treatment of various medical conditions.

Q: What are the limitations of this study and what should be addressed in future research?

A: This study has several limitations, including the small sample size and the use of a specific type of sea cucumber extract. Future studies should aim to increase the sample size and use different types of sea cucumber extracts to confirm the results. Additionally, the study should be replicated in humans to confirm the effectiveness of the combination of sand cucumber combinations and dragon fruit skin in accelerating the healing of oral mucositis.

Q: What are the potential applications of this research in the development of new treatments for oral mucositis?

A: The results of this study suggest that the combination of natural ingredients may be a safer and more effective treatment option for patients with oral mucositis. Further research is needed to explore the therapeutic potential of sea cucumber extracts and dragon fruit skin in the treatment of various medical conditions.