Characterization of Mobe Leaf Simplicia

Oct 13, 2025 by wbrum.org 97 views

Introduction

Mobe leaves, a medicinal plant native to Southeast Asia, including Indonesia, have been used for centuries due to their rich content of secondary metabolites such as flavonoids, tannins, saponins, and glycosides. These compounds have been shown to possess therapeutic properties, making mobe leaves a valuable resource for natural medicine. In this study, we aimed to formulate and evaluate the physical stability of nanogel dosage forms using ethanol extract from mobe leaves. The use of nanogel technology has gained significant attention in recent years due to its ability to increase the penetration and absorption of active compounds in the body.

Background

Nanogel is a type of hydrogel that has a particle size in the nanometer range, making it an ideal carrier for active compounds. The use of nanogel technology has been shown to improve the bioavailability of drugs, reduce side effects, and enhance the therapeutic efficacy of various medications. In this study, we utilized ethanol extract from mobe leaves as the active compound, which is rich in secondary metabolites with potential therapeutic properties.

Research Methods

The research process began with the manufacture of mobe leaf simplicia through the drying process, followed by testing characteristics and screening. Extraction was carried out using a maceration method with 96% ethanol, which was then tested for characteristics and screening. For nanogel formulations, carbopol 940 and HPMC K4M were used as a basis for gel, with variations in the concentration of mobe leaf extract at 1%, 3%, and 5%. Evaluation of nanogel preparations included observation of organoleptic, homogeneity, pH, viscosity, scatter power, stability, and measurement of particle size.

Characterization of Mobe Leaf Simplicia

The results of the characteristics of the simplicia of Mobe leaves showed a pretty good content, with water content, water soluble juice, ethanol soluble juice, total ash, and insoluble ash in a row of 6.65%, 25.37%, 15.94%, 6.95%, and 0.68%. These results indicate that the simplicia of Mobe leaves is rich in water-soluble compounds, which is consistent with its traditional use as a medicinal plant.

Characterization of Mobe Leaf Extract

The analysis of mobe leaf extract showed that it contains water content, total ash, and acid-soluble ash respectively 4.64%, 5.30%, and 0.62%. These results indicate that the extract is rich in secondary metabolites, which are known to possess therapeutic properties.

Formulation and Evaluation of Nanogel

The results of the nanogel formulation showed a brown preparation with a distinctive, homogeneous aroma, and has a pH ranging from 5.96 to 6.31. Nanogel spread power reached 5.03 to 6.70 cm, while viscosity ranged from 3871.00 to 5327.67 CP. The stability of the nanogel tested for 12 weeks at room temperature showed that this preparation remains stable, and the size of the preparation particle is within the range of 71 to 212 Nm.

Conclusion

Ethanol extract of Mobe leaf successfully formulated into a stable nanogel, fulfilling all physical evaluation requirements. This preparation has the potential to be used in pharmaceutical applications because of its ability to increase penetration and absorption of active compounds. This study opens the possibility of further utilization of mobe leaves as an effective source of natural medicine. With a better understanding of the formulation and stability of nanogel, it is expected to be further developed for clinical use in the future.

Future Directions

The results of this study provide a foundation for further research on the use of nanogel technology in the development of natural medicine products. Future studies should focus on the evaluation of the therapeutic efficacy of nanogel dosage forms using ethanol extract from mobe leaves. Additionally, the use of other natural extracts as active compounds in nanogel formulations should be explored to expand the range of potential therapeutic applications.

Limitations

This study has several limitations that should be addressed in future research. Firstly, the use of a single type of natural extract as the active compound may limit the potential therapeutic applications of the nanogel dosage form. Secondly, the evaluation of the physical stability of the nanogel was limited to a single time point, and further studies should investigate the long-term stability of the preparation. Finally, the use of a single type of polymer as the basis for gel may limit the flexibility of the nanogel formulation.

Conclusion

In conclusion, this study demonstrates the potential of nanogel technology in the development of natural medicine products using ethanol extract from mobe leaves. The results of this study provide a foundation for further research on the use of nanogel technology in the development of natural medicine products. With a better understanding of the formulation and stability of nanogel, it is expected to be further developed for clinical use in the future.

Frequently Asked Questions

Q: What is the purpose of this study?

A: The purpose of this study is to formulate and evaluate the physical stability of nanogel dosage forms using ethanol extract from mobe leaves.

Q: What is nanogel technology?

A: Nanogel is a type of hydrogel that has a particle size in the nanometer range, making it an ideal carrier for active compounds.

Q: What are the potential therapeutic applications of nanogel dosage forms using ethanol extract from mobe leaves?

A: The ethanol extract from mobe leaves is rich in secondary metabolites with potential therapeutic properties, making it a valuable resource for natural medicine.

Q: What are the limitations of this study?

A: This study has several limitations that should be addressed in future research, including the use of a single type of natural extract as the active compound, the evaluation of the physical stability of the nanogel at a single time point, and the use of a single type of polymer as the basis for gel.

Q: What are the future directions for this research?

A: The results of this study provide a foundation for further research on the use of nanogel technology in the development of natural medicine products. Future studies should focus on the evaluation of the therapeutic efficacy of nanogel dosage forms using ethanol extract from mobe leaves and the use of other natural extracts as active compounds in nanogel formulations.

Q: What are the potential benefits of using nanogel technology in the development of natural medicine products?

A: The use of nanogel technology in the development of natural medicine products has the potential to improve the bioavailability of active compounds, reduce side effects, and enhance the therapeutic efficacy of various medications.

Q: What are the potential challenges in the development of nanogel dosage forms using ethanol extract from mobe leaves?

A: The development of nanogel dosage forms using ethanol extract from mobe leaves may be challenging due to the complexity of the formulation process and the need for precise control over the particle size and distribution of the nanogel.

Q: What are the potential applications of nanogel dosage forms using ethanol extract from mobe leaves?

A: The potential applications of nanogel dosage forms using ethanol extract from mobe leaves include the treatment of various diseases and conditions, such as inflammation, pain, and cancer.

Q: What are the potential risks associated with the use of nanogel technology in the development of natural medicine products?

A: The potential risks associated with the use of nanogel technology in the development of natural medicine products include the potential for adverse reactions, the need for precise control over the particle size and distribution of the nanogel, and the potential for contamination.

Q: What are the potential benefits of using natural extracts as active compounds in nanogel formulations?

A: The use of natural extracts as active compounds in nanogel formulations has the potential to improve the bioavailability of active compounds, reduce side effects, and enhance the therapeutic efficacy of various medications.

Q: What are the potential challenges in the use of natural extracts as active compounds in nanogel formulations?

A: The use of natural extracts as active compounds in nanogel formulations may be challenging due to the complexity of the formulation process and the need for precise control over the particle size and distribution of the nanogel.

Q: What are the potential applications of natural extracts as active compounds in nanogel formulations?

A: The potential applications of natural extracts as active compounds in nanogel formulations include the treatment of various diseases and conditions, such as inflammation, pain, and cancer.

Q: What are the potential risks associated with the use of natural extracts as active compounds in nanogel formulations?

A: The potential risks associated with the use of natural extracts as active compounds in nanogel formulations include the potential for adverse reactions, the need for precise control over the particle size and distribution of the nanogel, and the potential for contamination.

Conclusion

In conclusion, this Q&A article provides a comprehensive overview of the formulation and evaluation of physical stability nanogel dosage ethanol extract Mobe leaves (Artocarpus Lacucha Buch.-Ham). The results of this study demonstrate the potential of nanogel technology in the development of natural medicine products using ethanol extract from mobe leaves. The potential benefits and challenges of using nanogel technology in the development of natural medicine products are discussed, as well as the potential applications and risks associated with the use of natural extracts as active compounds in nanogel formulations.